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The valence of the microorganisms can be determined by urgent evenly on the cover slip with a pointed object like the tip of a pen. When crimson blood cells grow to be infested with the higher valence development types of the first parasite, their urge to merge pulls the RBCs collectively. Copulation between high valence microorganisms on adjacent RBC membranes account for https://wiki.lerepair.org the rouleau formations. The presence of massive rouleau might be detrimental to patients suffering from occlusive vascular diseases because it causes impairment of blood circulate in the small vessels that may compromise the pink blood cells’ potential to change carbon dioxide and oxygen gases. This may cause greater blood stress so as to increase the supply of blood and oxygen to the tissue. Peripheral blood smears display rouleau when elements that improve ESR (erythrocyte sedimentation charge) are current. Anemia, by rising the ratio of RBCs to plasma, will increase rouleau formation and accelerates sedimentation.

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